Abstract
“Although the active component of cannabis Delta9-THC was isolated by our group 35 years ago, until recently its mode of action remained obscure. In the last decade it was established that Delta9-THC acts through specific receptors – CB1 and CB2 – and mimics the physiological activity of endogenous cannabinoids of two types, the best known representatives being arachidonoylethanolamide (anandamide) and 2-arachidonoylglycerol (2-AG). THC is officially used against vomiting caused by cancer chemotherapy and for enhancing appetite, particularly in AIDS patients. Illegally, usually by smoking marijuana, it is used for ameliorating the symptoms of multiple sclerosis, against pain, and in a variety of other diseases. A synthetic cannabinoid, HU-211, is in advanced clinical tests against brain damage caused by closed head injury. It may prove to be valuable against stroke and other neurological diseases.”
As someone who had a nerve injury and as one fo the three legal reasons to use cannibis legally, I really hope researchers can break out of not speaking to patients to really understand the impact. Let me just say that I want nothing to do with a synthetic. It negates the whole plant. It doesn’t need to be adjusted without input from patients. I can’t keep food down at different points in time due to my condition. Then, I don’t want to eat. I lose nutrition and get weaker. Without cannabis, I don’t know what I’d do. What I don’t like is that this lame veil in research means our doctors won’t even accurately and completely record the impact of cannabis so there is self-censorship from doctors. You guys can’t learn that way. I wish I could work with medicinal growers in a serious fashion to test the different parts of the plant and find the right combination for my body. But, I don’t want a pharm substitute. Please open up your minds and your studies and start caring about curing. Please.