Synthetic cannabis: a comparison of patterns of use and effect profile with natural cannabis in a large global sample.

“Natural cannabis was preferred to synthetic cannabis by 93% of users, with natural cannabis rated as having greater pleasurable effects when high and being more able to function after use. Synthetic cannabis was associated with more negative effects, hangover effects, and greater paranoia…

Users report a strong preference for natural over synthetic cannabis…”

http://www.ncbi.nlm.nih.gov/pubmed/23291209

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