“To evaluate, through a systematic review of the literature, the antitumoral effects of cannabinoids on gliomas…
In all experimental studies included, cannabinoids exerted antitumoral activity in vitro and/or antitumoral evidence in vivo in several models of tumor cells and tumors.
The antitumor activity included: antiproliferative effects (cell cycle arrest), decreased viability and cell death by toxicity, apoptosis, necrosis, autophagy, as well as antiangiogenic and antimigratory effects.
Antitumoral evidence included: reduction in tumor size, antiangiogenic, and antimetastatic effects.
Additionally, most of the studies described that the canabinnoids exercised selective antitumoral action in several distinct tumor models. Thereby, normal cells used as controls were not affected.
The safety factor in the cannabinoids’ administration has also been demonstrated in vivo.
The various cannabinoids tested in multiple tumor models showed antitumoral effects both in vitro and in vivo.
These findings indicate that cannabinoids are promising compounds for the treatment of gliomas.”