“Since the cannabinoid CB1 receptor modulates various types of aversive responses, this study tested the hypothesis that enhancement of endocannabinoid signalling in the dorsolateral periaqueductal grey inhibits panic-like reactions in rats…
The present results confirm the anti-aversive property of direct CB1 receptor activation in the dorsolateral periaqueductal grey…
Altogether, these results suggest that anandamide signalling is recruited only under certain types of aversive stimuli.”