New research shows marijuana compounds do fight cancer

The bracts surrounding a cluster of Cannabis sativa flowers are coated with cannabinoid-laden trichomes. (Photo: Wikimedia Commons)

“Debate is just beginning in Washington over how medical marijuana will be grown and distributed now that the rules for the recreational market are established. Meanwhile, research into medical benefits of compounds within the cannabis plant continues to show effectiveness.

Effectiveness against pain in its many forms and other side effects of major diseases – or the palliative side of marijuana use – have been pretty well established, but can marijuana directly take on a disease as big, scary and deadly as cancer?

“What we’ve shown using just a few of these (cannabis) compounds is that the effects against cancer are really profound. They really are,” said Dr. Wai Liu, a senior research fellow at St George’s University of London.

Anticancer success

Quick note: Cannabinoids are the chemicals in marijuana that have effects in the body, some have psychoactive (or make you high) effects such as THC, and others such as CBD don’t have psychoactive effects but do interact with the body’s “cannabinoid receptors.” There are more than 85 “cannabinoids” in marijuana.

Liu’s most recent published research “explored the activity of six cannabinoids, used both alone and in combination in leukaemic cells.” The research was published in Anticancer Research: International Journal of Cancer Research and Treatment.

He said the anticancer activity of THC has been “known for sometime” but that THC’s psychoactive effect or tendency to get you high limits its use as a cancer-fighting agent. That’s partly due to the negative social stigma about getting high and, of course, not everyone wants to experience a high.

So, he set out to explore the cancer fighting ability of other cannabinoids that don’t get you high.

“We have shown that these six other agents that lack psychoactivity are also just as effective as an anti-cancer agent,” he said. Chief among the six was cannabidiol or CBD.”

More: http://blog.seattlepi.com/marijuana/2013/10/22/new-research-shows-marijuana-compounds-do-fight-cancer/

Non-Hallucinogenic Cannabinoids Could Cure Cancer: Is A Cheap Anti-Cancer Drug On The Way?

Non-Hallucinogenic Cannabinoids

“Studies that support marijuana’s medicinal properties are met with a great deal of skepticism due to cannabis’ hallucinogenic effects. Researchers from St. George’s University of London have isolated six non-hallucinogenic cannabinoids that could lead to the development of effective anti-cancer medication.

“This study is a critical step in unpicking the mysteries of cannabis as a source of medicine,” explained the study’s lead researcher, Dr. Wai Liu. “The cannabinoids examined have minimal, if any, hallucinogenic side effects, and their properties as anti-cancer agents are promising.””

More: http://www.medicaldaily.com/non-hallucinogenic-cannabinoids-could-cure-cancer-cheap-anti-cancer-drug-way-259962

Molecular Mechanisms Involved in the Antitumor Activity of Cannabinoids on Gliomas: Role for Oxidative Stress.

“Cannabinoids, the active components of Cannabis sativa, have been shown to exert antiproliferative and proapoptotic effects on a wide spectrum of tumor cells and tissues.

Of interest, cannabinoids have displayed great potency in reducing the growth of glioma tumors, one of the most aggressive CNS tumors, either in vitro or in animal experimental models curbing the growth of xenografts generated by subcutaneous or intrathecal injection of glioma cells in immune-deficient mice.

Cannabinoids appear to be selective antitumoral agents as they kill glioma cells without affecting the viability of non-transformed cells.

This review will summarize the anti-cancer properties that cannabinoids exert on gliomas and discuss their potential action mechanisms that appear complex, involving modulation of multiple key cell signaling pathways and induction of oxidative stress in glioma cells.” http://www.ncbi.nlm.nih.gov/pubmed/24281104

“The therapy of gliomas, the most frequent class of malignant primary brain tumors and one of the most aggressive forms of cancer characterized by high invasiveness, a high proliferation rate and rich neovascularization, could benefit from the use of cannabinoids, the active compounds of Cannabis sativa, and their synthetic derivatives. They have been shown to mimic the endogenous substances named “endocannabinoids” that activate specific cannabinoid receptors (CB1 and CB2).

Cannabinoids have been proven to inhibit glioma tumor growth in either in vitro or in vivo models through several cellular pathways such as elevating ceramide levels, modulating PI3K/Akt, MAPK kinases, inducing autophagy and oxidative stress state in glioma cells, thus arresting cell proliferation and inducing apoptosis. Since cannabinoids kill tumor cells without toxicity on their non transformed counterparts, probably modulating the cell survival/cell death pathways differently, they can represent a class of new potential anticancer drugs.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835116/

http://www.thctotalhealthcare.com/category/gllomas/

Cannabinoids (Marijuana Compounds) Lead to Leukemia Cancer Cell Destruction

marijuana anti cancer 263x166 Cannabinoids (Marijuana Compounds) Lead to Leukemia Cancer Cell Destruction

 “As new studies are released showing just how miraculous the compounds of marijuana are, the argument for legalized marijuana or at least legal access to medicinal marijuana seems to build a little more each month.

One new study, from researchers with Saint George’s University of London and published in Anticancer Research, reveals how various compounds within cannabis are able to work together to kill human leukemia cells.

The study looked at three non-psychoactive cannabinoids, including cannabidiol, cannabigerol, and cannabigevarin. These compounds were tested on two leukemia cell lines where they acted synergistically to fight the cancerous cells.

According to a press release from the University, these “non-hallucinogenic components of cannabis could act as effective anti-cancer agents.””

Read more: http://naturalsociety.com/cannabinoids-marijuana-kill-leukemia-cancer-cells/

Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells through a Multitarget Effect.

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“…the non-psychoactive cannabinoid compound cannabidiol (CBD) effectively limits human glioma cell growth, both in vitro and in vivo… the present investigation confirms the antiproliferative and antiinvasive effects of CBD in U87-MG cells.

 More interestingly, these effects can also be extended to T98G glioma cells, a well known Δ9-THC-resistant lineage…

Taken together, these results provide new insights into the antitumor action of CBD, showing that this cannabinoid affects multiple tumoral features and molecular pathways.

 As CBD is a non-psychoactive phytocannabinoid that appears to be devoid of side effects, our results support its exploitation as an effective anti-cancer drug in the management of gliomas.”

 http://www.ncbi.nlm.nih.gov/pubmed/24204703

Full-text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804588/

New Study: Cannabis May Help Cure Cancer

“A recent study shows that cannabis, at least its non-hallucinogenic elements, could serve as a valuable ally in not only treating cancer patients suffering from a myriad of debilitating symptoms, but it could also cure them of the deadly disease.

According to researchers at St. George Hospital Medical School, a subsidiary of the University of London, there is significant evidence that suggests certain cannabinoids found in marijuana could be used as a highly effective anti-cancer drug without patients being forced to experience the psychotropic effects of its use.

“This study is a critical step in unpicking the mysteries of cannabis as a source of medicine,” said Dr. Wai Liu, lead author of this research. “The cannabinoids examined have minimal, if any, hallucinogenic side effects, and their properties as anti-cancer agents are promising. These agents are able to interfere with the development of cancerous cells, stopping them in their tracks and preventing them from growing. In some cases, by using specific dosage patterns, they can destroy cancer cells on their own.””

More: http://www.hightimes.com/read/new-study-cannabis-may-help-cure-cancer

Study: Cannabis Compounds Can Kill Cancer Cells – US News & World Report

“Researcher says cannabinoids might treat cancer as well as billion-dollar drugs.”

A medical marijuana activist holds a sign during a rally Jan. 4, 2010, in Oakland, Calif. Research suggests marijuana may fight cancer itself, not just side-effects.“A British researcher has found that cannabinoids, a term for chemicals derived from marijuana, can kill leukemia cells, and he expects clinical trials for new medications to begin soon.

The findings, published in the October issue of Anticancer Research: International Journal of Cancer Research and Treatment, show that certain non-psychoactive cannabinoids “resulted in dramatic reductions in cell viability” and “caused a simultaneous arrest at all phases of the cell cycle,” according to an abstract posted online. 

The study tested six cannabinoids, together and independently, on leukemia cells. Study author Wai Liu, an oncologist at the University of London’s St. George’s medical school, told U.S. News the chemicals displayed “potent anti-cancer activity” and, significantly, “target and switch off” pathways that allow cancers to grow.”

More: http://www.usnews.com/news/articles/2013/10/24/study-cannabis-compounds-can-kill-cancer-cells

Marijuana Compounds Possess Synergistic Anti-Cancer Effects, Study Says

“Marijuana’s active compounds act synergistically to inhibit the growth of cancer cells and induce malignant cell death, according to preclinical trial data published online by the journal Molecular Cancer Therapeutics.

Investigators at the University of California, Pacific Medical Center Research Institute assessed whether the administration of the non-psychoactive cannabidiol would enhance the anti-cancer effects of THC on glioblastoma (brain cancer) cells.

Researchers reported that a combination of cannabinoids showed greater anti-cancer activity than the administration of either compound individually. “We discovered that cannabidiol enhanced the ability of THC to inhibit cell proliferation and induce cell cycle arrest and apoptosis (programmed cell death),” authors reported.

Investigators concluded: “Individually, THC and cannabidiol can activate distinct pathways in glioblastoma cells that ultimately culminate in inhibition of cancer cell growth and invasion as well as induction of cell death. We hypothesized that, if the individual agents were combined, a convergence on shared pathways may ensue, leading to an enhanced ability of the combination treatment to inhibit certain cancer cell phenotypes. We found this to be true in this investigation.”

A 2008 scientific review published in the journal Cancer Research reported that the cannabinioids inhibit cell proliferation in a wide range of cancers, including brain cancer, prostate cancer, breast cancer, lung cancer, skin cancer, pancreatic cancer, and lymphoma.”

http://norml.org/news/2010/01/21/marijuana-compounds-possess-synergistic-anti-cancer-effects-study-says

Anti-cancer effects of curcumin (CUR) and tetrahydrocurcumin (THC) – Science

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“Anticancer potential of curcumin: preclinical and clinical studies.” http://www.ncbi.nlm.nih.gov/pubmed/12680238

“Tetrahydrocurcumin is more effective than curcumin in preventing… colon carcinogenesis. Tetrahydrocurcumin (THC), a major metabolite of curcumin (CUR), has been demonstrated to be anti-cancerogenic and anti-angiogenic…these results demonstrated for the first time the in vivo chemopreventive efficacy and molecular mechanisms of dietary THC…”  http://www.ncbi.nlm.nih.gov/pubmed/21887819

“Tetrahydrocurcumin inhibits HT1080 cell migration and invasion via downregulation of MMPs and uPA.” http://www.ncbi.nlm.nih.gov/pubmed/18565284

“Plant-derived anticancer agents – curcumin in cancer prevention and treatment.”  http://www.ncbi.nlm.nih.gov/pubmed/23700916

“Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701520/

“Mechanisms of cancer chemoprevention by curcumin.” http://www.ncbi.nlm.nih.gov/pubmed/11370761 

“Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells.” http://www.ncbi.nlm.nih.gov/pubmed/21928294

 “Synergistic anticancer activity of curcumin and catechin: an in vitro study using human cancer cell lines.” http://www.ncbi.nlm.nih.gov/pubmed/21780253 

“Synergistic anticancer effects of curcumin and resveratrol in Hepa1-6 hepatocellular carcinoma cells.” http://www.ncbi.nlm.nih.gov/pubmed/23446753

“Curcumin enhances the anticancer effects of trichostatin a in breast cancer cells.” http://www.ncbi.nlm.nih.gov/pubmed/22290509

 “Curcumin polymers as anticancer conjugates.” http://www.ncbi.nlm.nih.gov/pubmed/20591475

“Curcumin Potentiates The Ability of Sunitinib to Eliminate the VHL-lacking Renal Cancer Cells 786-O: Rapid Inhibition of Rb Phosphorylation as a Preamble to Cyclin D1 Inhibition.” http://www.ncbi.nlm.nih.gov/pubmed/23848205

 “RL66 a second-generation curcumin analog has potent in vivo and in vitro anticancer activity in ER‑negative breast cancer models.” http://www.ncbi.nlm.nih.gov/pubmed/22971638

“ApoE3 mediated polymeric nanoparticles containing curcumin: apoptosis induced in vitro anticancer activity against neuroblastoma cells.” http://www.ncbi.nlm.nih.gov/pubmed/22890189

 “Inclusion complex of novel curcumin analogue CDF and β-cyclodextrin (1:2) and its enhanced in vivo anticancer activity against pancreatic cancer.” http://www.ncbi.nlm.nih.gov/pubmed/22322899

“Water-soluble antioxidants improve the antioxidant and anticancer activity of low concentrations of curcumin in human leukemia cells.” http://www.ncbi.nlm.nih.gov/pubmed/15700780

“Superior anticancer efficacy of curcumin-loaded nanoparticles against lung cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23786839

“Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers.” http://www.ncbi.nlm.nih.gov/pubmed/21603867

“Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin.” http://www.ncbi.nlm.nih.gov/pubmed/23485682

 “Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent.” http://www.ncbi.nlm.nih.gov/pubmed/18496811

“Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric.” http://www.ncbi.nlm.nih.gov/pubmed/23847105

“Perspectives on new synthetic curcumin analogs and their potential anticancer properties.” http://www.ncbi.nlm.nih.gov/pubmed/23116312

“Synthesis and evaluation of curcumin-related compounds for anticancer activity.” http://www.ncbi.nlm.nih.gov/pubmed/22551677

 “Curcumin and its analogues: potential anticancer agents.” http://www.ncbi.nlm.nih.gov/pubmed/20027668

“Safe and targeted anticancer therapy for ovarian cancer using a novel class of curcumin analogs.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665575/

“Highly active anticancer curcumin analogues.” http://www.ncbi.nlm.nih.gov/pubmed/17569206 

Kurkumina

Marijuana Chemical May Fight Brain Cancer – CBSNews

“The active chemical in marijuana promotes the death of brain cancer cells by essentially helping them feed upon themselves, researchers in Spain report.

Guillermo Velasco and colleagues at Complutense University in Spain have found that the active ingredient in marijuana, THC, causes brain cancer cells to undergo a process called autophagy. Autophagy is the breakdown of a cell that occurs when the cell essentially self-digests.

The team discovered that cannabinoids such as THC had anticancer effects in mice with human brain cancer cells and people with brain tumors . When mice with the human brain cancer cells received the THC, the tumor growth shrank.

Two patients enrolled in a clinical trial received THC directly to the brain as an experimental treatment for recurrent glioblastoma multiforme , a highly aggressive brain tumor. Biopsies taken before and after treatment helped track their progress. After receiving the THC, there was evidence of increased autophagy activity.

The findings appear in the April 1 issue of the Journal of Clinical Investigation.

The patients did not have any toxic effects from the treatment. Previous studies of THC for the treatment of cancer have also found the therapy to be well tolerated, according to background information in journal article.

Study authors say their findings could lead to new strategies for preventing tumor growth.”

http://www.cbsnews.com/2100-500368_162-4913095.html

“Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells…These findings describe a mechanism by which THC can promote the autophagic death of human and mouse cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673842/