Tag Archives: anti-inflammatory

Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors.

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“∆9 -Tetrahydrocannabinol (THC), the active constituent of Cannabis sativa, exerts its biological effects in part through the G-protein-coupled CB1 and CB2 receptors, which were initially discovered in brain and spleen tissue, respectively. However, THC also has CB1/2 receptor-independent effects. Because of its immune-inhibitory potential, THC and related cannabinoids are being considered for the treatment of inflammatory skin diseases.

Here we investigated the mechanism of the anti-inflammatory activity of THC and the role of CB1 and CB2 receptors…

CONCLUSIONS:

Topically applied THC can effectively attenuate contact allergic inflammation by decreasing keratinocyte-derived pro-inflammatory mediators that orchestrate myeloid immune cell infiltration independent of CB1/2 receptors.

This has important implications for the future development of strategies to harness cannabinoids for the treatment of inflammatory skin diseases.”

http://www.ncbi.nlm.nih.gov/pubmed/23889474

Medical Marijuana is Being Used to Successfully Treat the Symptoms of Lupus in Patients

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“Cannabis is considered an ideal medication to help Lupus patients cope with the symptoms of the disorder like nausea and pain. It’s also known to be an anti-inflammatory, suppressing certain parts of the immune system.”

“By lowering the levels of the inflammation-promoting protein interleukin-2, and raising levels of the anti-inflammatory protein interleukin-10, cannabis shows that it may be beneficial for treating autoimmune disorders where inflammation is the main complication.”

“There is no doubt that cannabis has some medicinal benefits, and helps patients to cope with symptoms of Lupus. On the contrary, medical cannabis is only legal in a number of states. The naturally grown “drug” remains illegal on a federal level, so one should consider the law and its consequences before deciding to self-medicate. Even if you live in a state where cannabis is legal medicinally, always consult your doctor before using cannabis to treat your condition.”

More Helpful Medical Marijuana & Lupus Resources:

  • http://www.mcsocal.com/blog/plaquenil-rheumatoid-arthritis-lupus-and-marijuana-cannabis
  • http://cure4lupus.org/store/index.php?main_page=page&id=164&chapter=1
  • http://www.thelupussite.com/
  • http://www.medicalnewstoday.com/info/lupus/
  • http://www.lupus.org/newsite/index.html
  • http://lupus.webmd.com/news/20030415/cannabis-may-suppress-immune-system
  • http://www.webmd.com/rheumatoid-arthritis/features/autoimmune-disease-and-ra
  • http://www.mayoclinic.com/health/lupus/DS00115/DSECTION=alternative-medicine

More: http://www.medicaljane.com/2013/01/07/lupus-and-medical-marijuana/

Marijuana for migraines – USAToday

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“Does marijuana have medicinal value for migraine headaches and other maladies?

“There is no question that cannabis is beneficial medicinally,” Bearman says. With migraines, “some people say it makes the pain go completely away or can prevent migraines from coming on. Others say it lessens the pain and allows them to focus on other things to get their work done.”

What cannabis does to alleviate migraines is complicated and not completely understood. “But it works on serotonin and dopamine receptors, and has anti-inflammatory activity,” says Russo, who is just finishing a paper for the Journal of Cannabis Therapeutics.

“Basically, it is a multi-modality agent that works on various aspects of migraine in a way that’s really unique. And it’s not just the THC — tetrahydrocannabinol, the psychoactive chemical — that does it. It appears now that it’s the result of the interaction of a combination of other cannabinoids and also the essential oils in the plant.”

Unlike most headache medications, cannabis is unique in that it works as both a preventive agent and an analgesic. “At any point in the migraine, they could use cannabis by smoking, vaporizer, etc., and about 80% of these people get significant or total relief,” he says. “And, if someone has a chronic migraine, daily use in whatever form will often lead to a complete remission.””

http://usatoday30.usatoday.com/life/health/doctor/lhdoc227.htm

Marijuana may block Alzheimer’s

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“The active ingredient in marijuana may stall decline from Alzheimer’s disease, research suggests.” 

Brain

 

“Scientists showed a synthetic version of the compound may reduce inflammation associated with Alzheimer’s and thus help to prevent mental decline.

They hope the cannabinoid may be used to develop new drug therapies.”

More: http://news.bbc.co.uk/2/hi/health/4286435.stm

Marijuana: Miracle Cure For Crohn’s Disease?

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“Crohn’s disease is a autoimmunity deficiency in the gastronomical tract that can cause anything from mild stomach pains to vomiting and in extreme cases, chronic bloody diarrhea. There’s no cure for the disorder but now, researchers in Israel say they’ve found evidence that marijuana causes complete remission of the disease.

This news comes the Meir Medical Center in Israel, which treated 21 patients suffering from Crohn’s disease. 11 of the patients smoked two joints per day of cannabis sativa, which the researchers believed would provide anti-inflammatory relief, while the other (unlucky) 10 were only given a placebo. “The marijuana plant Cannabis sativa has been reported to produce beneficial effects for patients with inflammatory bowel diseases, but this has not been investigated in controlled trials,” the researchers argued. “We performed a prospective trial to determine whether cannabis can induce remission in patients with Crohn’s disease.”

Five of the 11 patients who smoked the weed, the study, which was published in the U.S. National Library of Medicine, states, acheived “total remission” of their disease, whereas only four of the 10 patients who didn’t smoke the pot reported only slight improvement of their condition. Needless to say, the study, while promising, only seems to suggest that more research should be undertaken. “Further studies, with larger patient groups and a nonsmoking mode of intake, are warranted,” the scientists argued.”

 http://blogs.ocweekly.com/navelgazing/2013/07/marijuana_miracle_cure_for_cro.php

[Marihuana and cannobinoids as medicaments].

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“Biological activity of cannabinoids is caused by binding to two cannabinoid receptors CB1 and CB2. Psychoactive is not only tetrahydrocannabinol (THC) but also: cannabidiol, cannabigerol or cannabichromen.

Formerly, the usefulness of hemp was assessed in the relation to temporary appeasement of the symptoms of some ailments as nausea or vomiting.

Present discoveries indicates that cannabis-based drugs has shown ability to alleviate of autoimmunological disorders such as: Multiple sclerosis (MS), Rheumatoid arthritis (RA) or inflammatory bowel disease.

Another studies indicates that cannabinoids play role in treatment of neurological disorders like Alzheimer disease or Amyotrophic lateral sclerosis (ALS) or even can reduce spreading of tumor cells.

Cannabinoids stand out high safety profile considering acute toxicity, it is low possibility of deadly overdosing and side-effects are comprise in range of tolerated side-effects of other medications.

In some countries marinol and nabilone are used as anti vomiting and nausea drug. First cannabis-based drug containg naturally occurring cannabinoids is Sativex. Sativex is delivered in an mucosal spray for patients suffering from spasticity in MS, pain relevant with cancer and neuropathic pain of various origin.

Cannabis side-effects varies and depend from several factors like administrated dose, rout of administration and present state of mind. After sudden break from long-lasting use, withdrawal symptoms can appear, although they entirely disappear after a week or two.”

http://www.ncbi.nlm.nih.gov/pubmed/23421098

Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis.

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“Cannabinoids from cannabis (Cannabis sativa) are anti-inflammatory and have inhibitory effects on the proliferation of a number of tumorigenic cell lines, some of which are mediated via cannabinoid receptors.

Cannabinoid (CB) receptors are present in human skin and anandamide, an endogenous CB receptor ligand, inhibits epidermal keratinocyte differentiation.

Psoriasis is an inflammatory disease also characterised in part by epidermal keratinocyte hyper-proliferation.

OBJECTIVE:

We investigated the plant cannabinoids Delta-9 tetrahydrocannabinol, cannabidiol, cannabinol and cannabigerol for their ability to inhibit the proliferation of a hyper-proliferating human keratinocyte cell line and for any involvement of cannabinoid receptors.

CONCLUSION:

The results indicate that while CB receptors may have a circumstantial role in keratinocyte proliferation, they do not contribute significantly to this process.

 Our results show that cannabinoids inhibit keratinocyte proliferation, and therefore support a potential role for cannabinoids in the treatment of psoriasis.”

http://www.ncbi.nlm.nih.gov/pubmed/17157480

Structure-dependent inhibitory effects of synthetic cannabinoids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and skin tumour promotion in mice.

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“Whether and how synthetic cannabinoids affect inflammation and carcinogenesis has not been well studied. The present study was thus conducted to assess effects of synthetic cannabinoids on inflammation and carcinogenesis in vivo in mice…

The present results suggest that synthetic cannabinoids, such as JWH-018, -122 and -210, may be used as cancer chemopreventive agents in the future.”

http://www.ncbi.nlm.nih.gov/pubmed/23837590

Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors.

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“Inflammation in the central nervous system (CNS) is a complex process that involves a multitude of molecules and effectors, and it requires the transmigration of blood leukocytes across the blood-brain barrier (BBB) and the activation of resident immune cells. Cannabidiol (CBD), a non-psychotropic cannabinoid constituent of Cannabis sativa, has potent anti-inflammatory and immunosuppressive properties.

 …Moreover, CBD administration at the time of viral infection exerts long-lasting effects, ameliorating motor deficits in the chronic phase of the disease in conjunction with reduced microglial activation and pro-inflammatory cytokine production. Adenosine A2A receptors participate in some of the anti-inflammatory effects of CBD…

Together, our findings highlight the anti-inflammatory effects of CBD in this viral model of MS, and demonstrate the significant therapeutic potential of this compound for the treatment of pathologies with an inflammatory component.”

http://www.ncbi.nlm.nih.gov/pubmed/23851307

Cannabinoid receptor subtypes 1 and 2 mediate long-lasting neuroprotection and improve motor behavior deficits after transient focal cerebral ischemia.

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“The endocannabinoid system is crucially involved in the regulation of brain activity and inflammation… we show that the endocannabinoid system assembles a comprehensive machinery to defend the brain against the devastating consequences of cerebral ischemia.

 In summary, this study underlines the therapeutic potential of CB1 and/or CB2 receptor agonists against neurodegenerative diseases or injuries involving acute or chronic imbalances of cerebral blood flow and energy consumption.”

http://www.ncbi.nlm.nih.gov/pubmed/23069763