“Cannabinoid inverse agonists possess antidepressant-like properties…
Numerous studies reported the interaction between opioid and cannabinoid pathways.
In this study, we used acute foot-shock stress in mice to investigate the involvement of opioid pathway in the antidepressant-like effect of the cannabinoid CB1 receptor inverse agonist AM-251.
In conclusion, the present study for the first time revealed the possible role of opioid signaling in the antidepressant-like properties of AM-251 in foot-shock stress model. “