[Study on the extraction process for cannabinoids in hemp seed oil by orthogonal design].
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Polyphenolic Compounds and Antioxidant Activity of Cold-Pressed Seed Oil from Finola Cultivar of Cannabis sativa L.
“The aim of this study was to characterize the polyphenolic compounds and antioxidant activity of cold-pressed seed oil from Finola cultivar of industrial hemp (Cannabis sativa L.).
Several methodologies have been employed to evaluate the in vitro antioxidant activity of Finola hempseed oil (FHSO) and both lipophilic (LF) and hydrophilic fractions (HF). The qualitative and quantitative composition of the phenolic fraction of FHSO was performed by HPLC analyses.
From the results is evident that FHSO has high antioxidative activity, as measured by DPPH radical (146.76 mmol of TE/100 g oil), inhibited β-carotene bleaching, quenched a chemically generated peroxyl radical in vitro and showed high ferrous ion chelating activity. Reactivity towards 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical cation and ferric-reducing antioxidant power values were 695.2 µmol of TE/100g oil and 3690.6 µmol of TE/100 g oil respectively.
FHSO contains a significant amount of phenolic compounds of which 2780.4 mg of quercetin equivalent/100 g of total flavonoids.
The whole oil showed higher antioxidant activity compared with LF and HF.
Our findings indicate that the significant antioxidant properties shown from Finola seed oil might generally depend on the phenolic compounds, especially flavonoids, such as flavanones, flavonols, flavanols and isoflavones.”
Cannabidiol Oil for Decreasing Addictive Use of Marijuana: A Case Report.
“This case study illustrates the use of cannabidiol (CBD) oil to decrease the addictive use of marijuana and provide anxiolytic and sleep benefits.
The second most abundant component-CBD-has been suggested to have the medicinal effects of decreasing anxiety, improving sleep, and other neuro-protective effects.
The mechanism of action for CBD has been suggested to be antagonistic to the psychoactive properties of THC in many locations within the central nervous system. Such action raises the issue of whether it might be beneficial to use CBD in isolation to facilitate withdrawal of marijuana use.
With use of the CBD oil, the patient reported being less anxious, as well as settling into a regular pattern of sleep. He also indicated that he had not used any marijuana since starting the CBD oil. With the decrease in the dosage to 18 mg, the patient was able to maintain his nonuse of marijuana.”
β-Caryophyllene potently inhibits solid tumor growth and lymph node metastasis of B16F10 melanoma cells in high-fat diet-induced obese C57BL/6N mice.
“…high-fat diet (HFD) feeding stimulated solid tumor growth and lymph node (LN) metastasis… β-caryophyllene (BCP) is a natural bicyclic sesquiterpene found in many essential oils and has been shown to exert anti-inflammatory activities….
BCP inhibits HFD-induced melanoma progression…
β-Caryophyllene potently inhibits solid tumor growth and lymph node metastasis of B16F10 melanoma cells in high-fat diet-induced obese C57BL/6N mice.” http://www.ncbi.nlm.nih.gov/pubmed/26025912
“β-caryophyllene (BCP) is a common constitute of the essential oils of numerous spice, food plants and major component in Cannabis.” http://www.ncbi.nlm.nih.gov/pubmed/23138934
Granite City Man Claims Cannabis Oil Cured His ‘Incurable’ Cancer
“Darren Miller is ready to enjoy his second chance at life.
The 50-year-old Granite City man is putting out the word that a steady diet of cannabis oil coupled with chemotherapy wiped out what doctors had only months earlier diagnosed as “incurable, inoperable” lung and pericardial heart sac cancer.
He’d basically been given about a year to live, with chemo.
“Glad to be here, glad to be anywhere with the diagnosis I had,” Miller said by way of introduction during a sitdown with KMOX News.
He carried with him a stack of medical documents to back his claim that he’s been given a clean bill of health just months after being handed a death sentence.
“I have the medical records to show the evidence of what I’m saying,” Miller said. “Now it’s going to be interpreted differently by people everywhere, but I’ve researched and there are thousands of testimonies that you can go on the internet and see every day people doing this and it’s been going on for years.”” http://stlouis.cbslocal.com/2016/01/22/granite-city-man-claims-cannabis-oil-killed-his-incurable-cancer/
“Granite City Man Claims Cannabis Oil Killed His “Incurable” Cancer” http://stlouis.suntimes.com/stl-news/7/139/238717/granite-city-man-claims-cannabis-oil-killed-his-incurable-cancer
CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience.
“To describe the experience of five Israeli pediatric epilepsy clinics treating children and adolescents diagnosed as having intractable epilepsy with a regimen of medical cannabis oil.
A retrospective study describing the effect of cannabidiol (CBD)-enriched medical cannabis on children with epilepsy.
The cohort included 74 patients (age range 1-18 years) with intractable epilepsy resistant to >7 antiepileptic drugs. Forty-nine (66%) also failed a ketogenic diet, vagal nerve stimulator implantation, or both.
They all started medical cannabis oil treatment between 2-11/2014 and were treated for at least 3 months (average 6 months).
The selected formula contained CBD and tetrahydrocannabinol at a ratio of 20:1 dissolved in olive oil. The CBD dose ranged from 1 to 20mg/kg/d. Seizure frequency was assessed by parental report during clinical visits.
CBD treatment yielded a significant positive effect on seizure load.
Most of the children (66/74, 89%) reported reduction in seizure frequency: 13 (18%) reported 75-100% reduction, 25 (34%) reported 50-75% reduction, 9 (12%) reported 25-50% reduction, and 19 (26%) reported <25% reduction. Five (7%) patients reported aggravation of seizures which led to CBD withdrawal.
In addition, we observed improvement in behavior and alertness, language, communication, motor skills and sleep. Adverse reactions included somnolence, fatigue, gastrointestinal disturbances and irritability leading to withdrawal of cannabis use in 5 patients.
CONCLUSIONS:
The results of this multicenter study on CBD treatment for intractable epilepsy in a population of children and adolescents are highly promising. Further prospective, well-designed clinical trials using enriched CBD medical cannabis are warranted.”
Hempseed as a nutritional resource: An overview
“The seed of Cannabis sativa L. has been an important source of nutrition for thousands of years in Old World cultures. Technically a nut, hempseed typically contains over 30% oil and about 25% protein, with considerable amounts of dietary fiber, vitamins and minerals. Hempseed oil is over 80% in polyunsaturated fatty acids (PUFAs), and is an exceptionally rich source of the two essential fatty acids (EFAs) linoleic acid (18:2 omega-6) and alpha-linolenic acid (18:3 omega-3). The omega-6 to omega-3 ratio (n6/n3) in hempseed oil is normally between 2:1 and 3:1, which is considered to be optimal for human health. Hempseed has been used to treat various disorders for thousands of years in traditional oriental medicine.” http://link.springer.com/article/10.1007%2Fs10681-004-4811-6
Safety and Efficacy of Medical Cannabis Oil for Behavioral and Psychological Symptoms of Dementia: An-Open Label, Add-On, Pilot Study.
“Tetrahydrocannabinol (THC) is a potential treatment for Alzheimer’s disease (AD).
OBJECTIVE:
To measure efficacy and safety of medical cannabis oil (MCO) containing THC as an add-on to pharmacotherapy, in relieving behavioral and psychological symptoms of dementia (BPSD).
Eleven AD patients were recruited to an open label, 4 weeks, prospective trial.
RESULTS:
Ten patients completed the trial. Significant reduction in CGI severity score and NPI score were recorded. NPI domains of significant decrease were: Delusions, agitation/aggression, irritability, apathy, and sleep and caregiver distress.
CONCLUSION:
Adding MCO to AD patients’ pharmacotherapy is safe and a promising treatment option.”
http://www.ncbi.nlm.nih.gov/pubmed/26757043
http://www.thctotalhealthcare.com/category/alzheimers-disease-ad/
Cannabidiol: promise and pitfalls.
“Over the past few years, increasing public and political pressure has supported legalization of medical marijuana.
One of the main thrusts in this effort has related to the treatment of refractory epilepsy-especially in children with Dravet syndrome-using cannabidiol (CBD).
Despite initiatives in numerous states to at least legalize possession of CBD oil for treating epilepsy, little published evidence is available to prove or disprove the efficacy and safety of CBD in patients with epilepsy. This review highlights some of the basic science theory behind the use of CBD, summarizes published data on clinical use of CBD for epilepsy, and highlights issues related to the use of currently available CBD products.
Cannabidiol is the major nonpsychoactive component of Cannabis sativa.
Over the centuries, a number of medicinal preparations derived from C. sativa have been employed for a variety of disorders, including gout, rheumatism, malaria, pain, and fever.
These preparations were widely employed as analgesics by Western medical practitioners in the 19(th) century.
More recently, there is clinical evidence suggesting efficacy in HIV-associated neuropathic pain, as well as spasms associated with multiple sclerosis.”
Patent: CA 2771800 A1: Herbal medication for cold sores and genital herpes and preparation thereof
“The present invention generally relates to herbal medications. More particularly, it relates to formulations to treat cold sores and genital herpes. The ingredients of this formulation are cannabis oil and cannabis roots, which are used to treat genital herpes, cold sores and other viral diseases.
SUMMARY OF THE INVENTION
The disclosed formulation comprises cannabis oil and cannabis root fibres. The person with herpes surrounds the lesion with the cannabis oil such that the lesion is completely covered. The root fibres are then applied over the oil-covered lesions.
Finally, medical gauze is applied over the treated areas and secured to the skin. Within 24 hours, the gauze may be removed. The herpes lesions heal and, of significance, outbreaks do not recur.
An individual genital herpes treatment comprises 1 gram of oil and 0.5 gram of root fibres.
CLAIMS
1. A formulation of cannabis oil and cannabis root powder to treat viral diseases, whereby there is no recurrence of the disease after one treatment.”