Evaluation of cannabinoids concentration and stability in standardized preparations of cannabis tea and cannabis oil by ultra-high performance liquid chromatography tandem mass spectrometry.

Posted on February 19, 2017 by David

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“Cannabis has been used since ancient times to relieve neuropathic pain, to lower intraocular pressure, to increase appetite and finally to decrease nausea and vomiting.

The combination of the psychoactive cannabis alkaloid Δ9-tetrahydrocannabinol (THC) with the non-psychotropic alkaloids cannabidiol (CBD) and cannabinol (CBN) demonstrated a higher activity than THC alone.

Extraction efficiency of oil was significantly higher than that of water with respect to the different cannabinoids.

Fifteen minutes boiling was sufficient to achieve the highest concentrations of cannabinoids in the cannabis tea solutions.

As the first and most important aim of the different cannabis preparations is to guarantee therapeutic continuity in treated individuals, a strictly standardized preparation protocol is necessary to assure the availability of a homogeneous product of defined stability.”

https://www.ncbi.nlm.nih.gov/pubmed/28207408

Health Benefits of Cannabis Tea

Posted on July 28, 2013 by David

“Reduces Chronic Pain

Reduces Anxiety

Reduces Nausea

May Treat Autoimmune Diseases”

http://www.livestrong.com/article/284221-health-benefits-of-cannabis-tea/

“Marijuana-Infused Tea… Mom always said a cup of tea at night makes it easier to sleep.. Kevin Reed, of The Green Cross medical marijuana dispensary in San Francisco, advises patients to add a little milk after brewing to get the full effect of the cannabis.” http://www.cbsnews.com/2300-204_162-10004358-12.html

“Cannabis Tea… Other names: Pot Tea, Weed Tea…Translations: Kaņepes Tēja, Kanapių arbata, Ceai de canabis, Kanabis Tea, Cần sa trà, Cannabis urządzenia, कैनबिस चाय, Chá de Cannabis, Каннабис чай, Η κάνναβη Τσάι, القنب الشاي, 대마초 차, Cannabis Čaj, Cannabis Teh, 大麻茶, Cannabis para preparar té, Cannabis Čaj, קנאביס תה, Канабис чај, 大麻コーヒー, Cannabis Te, Cannabis per a preparar te, Каннабіс чай, Kannabis Tea, Канабис чай” http://www.foodista.com/food/3HJ8KNK6/cannabis-tea#

“Cannabis tea revisited: a systematic evaluation of the cannabinoid composition of cannabis tea.” http://www.ncbi.nlm.nih.gov/pubmed/17604926

Medicinal Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel

Posted on July 28, 2013 by David

“For the past 4,000 years, patients and doctors of each era have resorted to cannabis when conventional treatments were ineffective or lacking. Indeed, in oncology beneficial effects have been reported for cancer-associated anorexia, chemotherapy-induced nausea and vomiting, and palliation…

The only U.S. Food and Drug Administration (FDA)-approved medicinal cannabis products are an oral formulation containing dronabinol (Marinol®)… the synthetic version of delta9-tetrahydrocannabinol (THC), the main pharmacologically active cannabinoid, and capsules containing nabilone, an analog of dronabinol (Cesamet®)…

…many patients claim (subjectively) that a whole or partially purified extract of Cannabis sativa L. offers advantages over a single isolated ingredient…

We anticipated an increased use of medicinal cannabis concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal cannabis on the pharmacokinetics of irinotecan and docetaxel…

Conclusion. Coadministration of medicinal cannabis, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs. The evaluated variety of medicinal cannabis can be administered concomitantly with both anticancer agents without dose adjustments.”

Full text: http://theoncologist.alphamedpress.org/content/12/3/291.long

Prevention of carcinogenesis by tea polyphenols – Science

Posted on July 28, 2013 by David

“Prevention of carcinogenesis by tea polyphenols… Tea has been considered a medicine and healthful beverage for ages. The beneficial effects of tea are thought to be due to its polyphenolic components….Tea is one of the few chemopreventive agents known to have protective effects at different stages of the carcinogenic process….” http://www.ncbi.nlm.nih.gov/pubmed/11768768

“Tea and tea polyphenols in cancer prevention… The inhibitory action of tea (Camellia sinensis) and tea components against cancer formation has been demonstrated in different animal models involving different organ sites in many laboratories… tea polyphenols affect signal transduction pathways, inhibit cell proliferation and induce apoptosis,” http://www.ncbi.nlm.nih.gov/pubmed/10721932

“Polyphenols as cancer chemopreventive agents.” http://www.ncbi.nlm.nih.gov/pubmed/8538195

“Mechanisms of inhibition of carcinogenesis by tea.” http://www.ncbi.nlm.nih.gov/pubmed/11237203

“Antioxidative and anti-carcinogenic activities of tea polyphenols” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820244/

“Cancer chemopreventive activity and bioavailability of tea and tea polyphenols… Consumption of tea has been associated with many health benefits including the prevention of cancer.” http://www.ncbi.nlm.nih.gov/pubmed/12628518

“Chemopreventive and therapeutic potential of tea polyphenols in hepatocellular cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23530632

“Cancer chemoprevention by tea polyphenols… Tea is one of the most widely consumed beverages, second only to water… inhibitory effects of tea against carcinogenesis… tea polyphenols function as cancer chemopreventive agents” http://www.ncbi.nlm.nih.gov/pubmed/10786933

“Tea antioxidants in cancer chemoprevention… properties of tea polyphenols make them effective chemopreventive agents against the initiation, promotion, and progression stages of multistage carcinogenesis.” http://www.ncbi.nlm.nih.gov/pubmed/9591194

“Chemopreventive potential of flavonoids in oral squamous cell carcinoma in human studies… These flavonoids, abundant in green tea and black raspberries, respectively, represent promising chemopreventive agents in human oral cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23857227

Cancer prevention by tea: Evidence from laboratory studies… The cancer preventive activities of tea (Camellia sinensis Theaceae) have been studied extensively. Inhibition of tumorigenesis by green tea extracts and tea polyphenols has been demonstrated in different animal models, including those for cancers of the skin, lung, oral cavity, esophagus, stomach, small intestine, colon, bladder, liver, pancreas, prostate, and mammary glands.” http://www.ncbi.nlm.nih.gov/pubmed/21397027

“Comparative antimutagenic and anticancer activity of three fractions of black tea polyphenols thearubigins.” http://www.ncbi.nlm.nih.gov/pubmed/21919645

“Hepatoprotective and antioxidant activity of standardized herbal extracts.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371432/

“[Anti-inflammatory effects of tea-flavonoids]… Tea flavonoids belong to the large group of polyphenols and display antioxidative, anti-inflammatory and anti-neoplastic activities… Dietary supplementation with specific tea-flavonoids… could ultimately lead to inhibition of carcinogenesis.” http://www.ncbi.nlm.nih.gov/pubmed/23233307

“Tea and health: Studies in humans.” http://www.ncbi.nlm.nih.gov/pubmed/23448443

“Prevention of chronic diseases by tea: possible mechanisms and human relevance.” http://www.ncbi.nlm.nih.gov/pubmed/23642203

“Active extracts of black tea (Camellia Sinensis) induce apoptosis of PC-3 prostate cancer cells via mitochondrial dysfunction… Many studies have shown that black tea reduces the risk of several types of cancer… these findings suggest that black tea could act as an effective anti-proliferative agent…” http://www.ncbi.nlm.nih.gov/pubmed/23715786

“Epicatechins Purified from Green Tea (Camellia sinensis) Differentially Suppress Growth of Gender-Dependent Human Cancer Cell Lines.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475929/

“Effects of green tea, black tea, and coffee consumption on the risk of esophageal cancer: a systematic review and meta-analysis of observational studies.” http://www.ncbi.nlm.nih.gov/pubmed/23368908

“Protective effect of green tea on the risks of chronic gastritis and stomach cancer.” http://www.ncbi.nlm.nih.gov/pubmed/11304697

“The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946098/

“Growth inhibition of Walker carcinosarcoma 256 with alcoholic extract of green tea leaves (Camellia sinensis).” http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000900008&lng=en&nrm=iso&tlng=en

“Health-promoting effects of green tea… anti-cancer, anti-obesity, anti-atherosclerotic, anti-diabetic, anti-bacterial, and anti-viral…” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365247/

“Meta-analysis of Green Tea Drinking and the Prevalence of Gynecological Tumors in Women… Our analysis indicates that drinking green tea can significantly decrease the risk of ovarian cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23858521

“Polyphenols in brewed green tea inhibit prostate tumor xenograft growth by localizing to the tumor and decreasing oxidative stress and angiogenesis… administration of green tea (GT) extracts in drinking water can inhibit tumor growth…” http://www.ncbi.nlm.nih.gov/pubmed/22405694

“Medicinal benefits of green tea: Part I. Review of noncancer health benefits.” http://www.ncbi.nlm.nih.gov/pubmed/15992239

“Medicinal benefits of green tea: part II. review of anticancer properties.” http://www.ncbi.nlm.nih.gov/pubmed/16131288

“Green tea (Camellia sinensis) extract and its possible role in the prevention of cancer.” http://www.ncbi.nlm.nih.gov/pubmed/10559550

“Green tea (Camellia sinensis) and cancer prevention: a systematic review of randomized trials and epidemiological studies” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577676/

“Green tea (Camellia sinensis) for the prevention of cancer.” http://www.ncbi.nlm.nih.gov/pubmed/19588362

“Green tea prevents non-melanoma skin cancer by enhancing DNA repair.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077767/

“Green tea inhibits cycolooxygenase-2 in non-small cell lung cancer cells through the induction of Annexin-1.” http://www.ncbi.nlm.nih.gov/pubmed/23036202

“Green tea for ovarian cancer prevention and treatment: a systematic review of the in vitro, in vivo and epidemiological studies.” http://www.ncbi.nlm.nih.gov/pubmed/22564714

“Green tea: an effective synergist with anticancer drugs for tertiary cancer prevention.” http://www.ncbi.nlm.nih.gov/pubmed/22626556

“Medicinal Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel… Coadministration of medicinal cannabis, as herbal tea, in cancer patients treated with irinotecan or docetaxel does not significantly influence the plasma pharmacokinetics of these drugs… medicinal cannabis can be administered concomitantly with both anticancer agents without dose adjustments.” http://theoncologist.alphamedpress.org/content/12/3/291.long

Cannabis tea revisited: a systematic evaluation of the cannabinoid composition of cannabis tea.

Posted on April 20, 2013 by David

“Cannabis is one of the oldest known medicinal plants, and a large variety of biological activities have been described. The main constituents, the cannabinoids, are thought to be most important for these activities. Although smoking of cannabis is by far the most common way of consumption, a significant part of medicinal users consume it in the form of a tea.

However, not much is known about the composition of cannabis tea, or the effect of different parameters during preparation, handling or storage. In this study we used the high-grade cannabis available in Dutch pharmacies to study the cannabinoid composition of tea under standardized and quantitative conditions. Experimental conditions were systematically varied in order to mimic the possible variations made by medicinal users.

During analysis there was a specific focus on the cannabinoid tetrahydrocannabinol and its acidic precursor, tetrahydrocannabinolic acid. Also the role of non-psychoactive cannabinoids as components of cannabis tea are discussed.

The results obtained in this study provide a clear quantitative insight in the phytochemistry of cannabis tea preparation and can contribute to a better appreciation of this mode of cannabis administration.”

http://www.ncbi.nlm.nih.gov/pubmed/17604926