“Our study addressed the hypothesis that spinal release of endogenous opioids underlies Delta9-tetrahydrocannabinol (Delta9-THC)-induced antinociception in Freund’s adjuvant-induced arthritic and nonarthritic rats…
Our results indicate that morphine or Delta9-THC is equally potent and efficacious in both nonarthritic and arthritic rats.
Delta9-THC-induced antinociception…
We hypothesize that the elevated idyn A level in arthritic rats contributes to hyperalgesia by interaction with N-methyl-D-aspartate receptors, and that Delta9-THC induces antinociception by decreasing idyn A release.”