“The function of the endocannabinoid system (ECS) in the renal tissue is not completely understood. Kidney function is closely related to ion reabsorption in the proximal tubule, the nephron segment responsible for the reabsorption of 70- 80% of the filtrate.
We studied the effect of compounds modulating the activity of cannabinoid CB receptors on the active reabsorption of Na+ in LLC-PK1 cells.
CONCLUSION AND IMPLICATIONS:
ECS is expressed in LLC-PK1 cells. Both CB1 and TRPV1 regulate (Na+ +K+ )-ATPase activity in these cells, and are modulated by lipid and peptide CB1 ligands, which act via different signaling pathways.”