“Recent studies have indicated that type 2 cannabinoid receptor (CB2R) agonists reduce neurodegeneration after brain injury through anti-inflammatory activity.
The purpose of this study was to examine the time-dependent interaction of CB2R and inflammation in stroke brain.
In conclusion, our data support a time-dependent neuroprotection of CB2 agonist in an animal model of stroke.
Delayed post- treatment with PPAR-γ agonist induced behavioral recovery and microglial suppression; early treatment with CB2R agonist suppressed neurodegeneration in stroke animals.”